THE  REASON FOR FAILUR OF BETA CELLS

 
The reason for the lack of beta-cell function at the same level with increasing demands observed in type II diabetes, is still unclear. Subtle defects in the function of beta cells are described during the early stages of the disease. One of the attractive theory is that she glucose when its concentration exceeds the normal limits, may actually turn out to be "toxic" to beta-cells.

This theory is supported by a number of studies in animals have shown that beta cells are not able to respond appropriately to glucose when its concentration in the ambient environment, these cells retained higher - 120 mg / dL. According to these studies, glucose may contribute to a vicious circle consisting of increased blood glucose and reduced beta-cell function. This acquired defect in the function of beta-cells, appears to be reversible if glucose levels are normal.

There are other causes dysfunction of beta cells that are important in the development of type II diabetes, including a genetically determined reduction in beta-cell mass and accumulation amiloidopodobnyh fibers in beta-cells (amylin).

The relative contribution of these factors is unknown. In the course of the disease beta-cell function in type II diabetes is reduced, may progress further and, eventually, go to the nosological form, similar to type I diabetes, which manifests severe insulin deficiency, or absolute and susceptibility to ketosis.